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The Oxford GI Biobank is primarily intended to provide validated biological samples in association with clinical data to support research into gastroenterological disease. The Biobank is strongly supported by the Translational Gastroenterology & Liver Unit (TGLU) that integrates the ORHT clinical department of Gastroenterology with the University of Oxford Nuffield Department of Medicine, Division of Experimental Medicine. Furthermore, by integrating the operation of the Biobank with the wider Oxford Radcliffe Biobank, samples will also be available to other researchers in the hospital, University, and more widely.

The major focus of research in the TGLU currently is inflammatory bowel disease, colorectal cancer, and innovative diagnostic and therapeutic approaches to these major diseases. Many samples in the Biobank will be derived from patients with IBD or with bowel cancer, and other samples, for instance from patients with irritable bowel syndrome, could form important control groups for comparison.

Typical uses of samples in the Biobank will include analysis of immunological and chemical changes associated with disease, characterisation of changes in cells and tissues with inflammation, and correlation of genetic background with disease activity.

Application Process for Project Proposals

The Biobank primarily supports research by academic investigators based in Oxford with an affiliation to, or collaborators within, the Translational Gastroenterology & Liver Unit (TGLU). Applications from investigators who do not have affiliation to the TGLU will be considered by the management committee on an individual basis.

Please download and complete the TGLU Sub-Project Application Form and save in the suggested name format NAME_SURNAME_DATE_TGLURequestForm. 

Click here  TGLU Sub-Project Application Form  to download a copy.

The form must be completely filled in with as much detail as possible to be considered. Request forms are reviewed each month at the TGLU Internal Committee meeting which is usually held on the third Thursday of the month.

Once a proposal has been submitted, it will be reviewed by the TGLU Internal Committee and a decision/ comments will be sent back to the PI and/or the person who submitted the form.

To amend any existing sub-projects, please submit your form with your existing project proposal and clearly mark your amendments in RED lettering.

A formal approval letter will be sent to the PI of the project, as well as a conduct form. Projects may only start collecting samples under our ethics once they have received approval either by email or by formal approval letter.

 *PLEASE NOTE DEADLINE FOR SUBMISSION* 

The application submission deadline is up to (not including) ONE week before the third Thursday of every month​. Applications received after this will be automatically transferred to the next month's meeting.

The Lead Applicant or contact person will be required to attend this review meeting which is held via Teams on the third Thursday of the month.

RECENT  APPLICATIONS

PI Name Title Contact Type Review Date
Parinaz Mehdipour  Circular RNAs as biomarkers for predicting healthy colon cell transformations towards precancerous lesions and then CRC
Parinaz.mehdipour@ludwig.ox.ac.uk  Amendment 15 Jan
Jo Fergusson Adjuvant-induced inflammation and vaccine responses in human lymph nodes joannah.fergusson@kennedy.ox.ac.uk Amendment 20 Nov
Lulia Al Hillawi The SPECTRAL Study – Study of Patterns of Ulcerative Colitis in the Real World  Lulia.al-hillawi@ouh.nhs.uk 
New 20 Nov
Prof Simon Travis AQUARIUS: Analysis and QUAntification of theRapeutIc oUtcome in Crohn’S disease-Amended 14/11/25 due to new funder and therefore new acronym Simon.travis@kennedy.ox.ac.uk  Amendment 20 Nov
Shazia Irshad Effect of Mesenchymal Stem Cell (MSC)-derived proteins (CEXCI™) on intestinal stem cells shazia.irshad@ndcls.ox.ac.uk  Amendment 16 Oct
Prof Simon Leedham Amendment to 20-SL-gastro-neoplasia   Simonl@well.ox.ac.uk  Amendment 16 Oct

Prof Katrina Pollock 

LEGACY04: An experimental medicine study of early tissue response in vaccination with lipid encapsulated non-amplifying mRNA in Lymph nodE single-cell Genomics in AnCestrY and ageing  Terrence.chan@paediatrics.ox.ac.uk  New 18 Sept

Vivian Li 

Jean-Paul (JP) Vincent 

Validation of biomarkers in colorectal cancer  lohj@crick.ac.uk  New 18 Sept
Ian Tomlinson Effect of germline polymorphisms on CRC risk  Ian.tomlinson@oncology.ox.ac.uk  New 19 Jun
Paul Klenerman Transcriptional and epigenetic landscape of mucosal-associated invariant T (MAIT) cells in healthy and diseased liver 

paul.klenerman@ndm.ox.ac.uk 

 lucy.garner@ndm.ox.ac.uk 

New 19 Jun

Parinaz Mehdipour

David Michael

Circular RNAs as biomarkers for predicting healthy colon cell transformations towards precancerous lesions and then CRC. 

Parinaz.mehdipour@ludwig.ox.ac.uk 

David.michael@ludwig.ox.ac.uk 

New 22 May