About the TGU
The Translational Gastroenterology Unit hosts teams of scientists and clinicians working together to tackle major diseases affecting the gut and the liver. This includes cancers, infections and inflammatory diseases. A longstanding interest of the unit is inflammatory bowel disease (ulcerative colitis and Crohn’s disease), dating back to the era of Sidney Truelove, who developed the first trials and treatments. Together we are now pursuing studies of vaccines, diagnostics, biomarkers, genetics and new clinical interventions in a range of diseases including celiac disease, intestinal failure and auto-immune liver diseases. The unit hosts the Sidney Truelove chair and the Lee Placito chair and around 15 PIs across the different university sites who study various aspects of GI disease at the interface of clinical medicine and basic science. It also hosts a core Flow Cytometry Facility that offers a high-quality Flow Cytometry service to a variety of users. The TGU and flow cytometry facility are supported by the Biomedical Research Centre and Human Immune Discovery Initiative.
Therapeutic vaccination for treatment of chronic hepatitis B.
Cargill T. and Barnes E., (2021), Clinical and experimental immunology, 205, 106 - 118
BashTheBug: a crowd of volunteers reproducibly and accurately measure the minimum inhibitory concentrations of 13 antitubercular drugs from photographs of 96-well broth microdilution plates.
Fowler PW. et al, (2021)
News and Events
13 May 2021
On 29 April 2021 leading clinicians and scientists from the Oxford Translational Gastroenterology Unit will present on the latest research into the causes, treatment and monitoring of Crohn’s and Colitis.
Featured TGU Researcher
Dr Oliver Brain is a Consultant Gastroenterologist at Nuffield Health The Manor Hospital, Oxford and at the Oxford University Hospitals NHS Trust. He has extensive experience in general gastroenterology and endoscopy, including diagnostic colonoscopy and therapeutic endoscopy. He has a research interest in the pathogenesis and treatment of inflammatory bowel disease.