About the TGU
The Translational Gastroenterology Unit hosts teams of scientists and clinicians working together to tackle major diseases affecting the gut and the liver. This includes cancers, infections and inflammatory diseases. A longstanding interest of the unit is inflammatory bowel disease (ulcerative colitis and Crohn’s disease), dating back to the era of Sidney Truelove, who developed the first trials and treatments. Together we are now pursuing studies of vaccines, diagnostics, biomarkers, genetics and new clinical interventions in a range of diseases including celiac disease, intestinal failure and auto-immune liver diseases. The unit hosts the Sidney Truelove chair and the Lee Placito chair and around 15 PIs across the different university sites who study various aspects of GI disease at the interface of clinical medicine and basic science. It also hosts a core Flow Cytometry Facility that offers a high-quality Flow Cytometry service to a variety of users. The TGU and flow cytometry facility are supported by the Biomedical Research Centre and Human Immune Discovery Initiative.
Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis
Sasson SC. et al, (2021), Gastroenterology, 161, 1229 - 1244.e9
Inborn errors of IL-6 family cytokine responses
Chen Y-H. et al, (2021), Current Opinion in Immunology, 72, 135 - 145
News and Events
21 September 2021
The fast spread of the highly infectious Delta variant underscores the need for faster identification of COVID-19 mutations. Uniting governments and medical communities in this challenge, the University of Oxford and Oracle’s Global Pathogen Analysis System (GPAS) is now being used by organizations on nearly every continent. Institutions using the platform include: the University of Montreal Hospital Centre Research Centre, the Institute of Public Health Research of Chile, the Oxford University Clinical Research Unit in Vietnam, the Institute of Clinical Pathology and Medical Research – New South Wales Pathology, and Oxford Nanopore Technologies. GPAS is also now part of the Public Health England New Variant Assessment Platform.
20 September 2021
‘Finding Our Way – An NHS Tribute Garden’ is a celebration of the incredible efforts of the thousands of people who fought – and are still fighting - the COVID-19 pandemic on our behalf. Designed by Naomi Ferrett-Cohen and presented by Oxford University Hospitals NHS Foundation Trust and Oxford University.
Featured TGU Researcher
Dr Oliver Brain is a Consultant Gastroenterologist at Nuffield Health The Manor Hospital, Oxford and at the Oxford University Hospitals NHS Trust. He has extensive experience in general gastroenterology and endoscopy, including diagnostic colonoscopy and therapeutic endoscopy. He has a research interest in the pathogenesis and treatment of inflammatory bowel disease.
Thursday, 02 December 2021, 4.30pm to 5.30pm
Thursday, 09 December 2021, 4.30pm to 5.30pm