Shazia Irshad

 1. How did you become interested in translational gastroenterology? 

My interest in translational research started from one of my research projects in the past which involved using mouse models to identify 3 age-related genes that turned out to be highly predictive in stratifying human indolent prostate cancers from lethal subtypes. While working in Oxford, my research has focussed on studying molecular mechanisms governing intestinal homeostasis. Using my previous experience, I hope to translate basic scientific discoveries from experimental model systems of the intestine to diagnose, treat and/or prevent colorectal cancers in humans.   

 2. What are you currently working on and what importance does your work hold for current patients with gastrointestinal issues? 

Currently, my lab is working on understanding somatic stem cell ageing in the intestine. We have identified a number of age-related genes which are being tested for reversing the ageing phenotype in the colon and in rejuvenating aged stem cells. In the longer term, we envisage our ageing signatures to be used in determining biological age of individuals undergoing routine colonoscopies and in assessing their risk in developing age-related diseases such as colorectal cancers.    

3. What do you enjoy most about scientific research? 

The best part of scientific research is the intellectual freedom it offers. From exploring ambitious research questions to seeing novel discoveries being applied to benefit human health is thoroughly enjoyable and worthwhile. 

4. What’s the best part of being an Oxford University TGLU member? 

Being a member of the TGLU at Oxford means I have the opportunity to work with medical and research staff who provide critical feedback and access to precious patient samples that have been instrumental in shaping my research interests. Without this support and collaboration, my research projects would not have been as ambitious and also would not have moved quickly enough to attract competitive funding required to deliver high quality research.