Researcher of the Month: Dr. Sumeet Pandey
How did you get interested in your scientific work? I did my PhD in Biochemistry working on the genetic engineering of a probiotic E. coli strain. While performing experiments we observed that administration of probiotic E. coli to rats resulted in substantial anti-inflammatory effects.
This observation made me curious to look into the host-microbe interactions from an immune prospective. I applied for a grant to support my research in Oxford in Holm Uhlig's lab and extended my studies from animal models to the human immune system. In Oxford I worked on the role of enzymes that generate reactive oxygen species in maintaining gut barrier function.
Q: What are you working on now?
Currently I am trying to understand immunopathology in an patients with a diverse spectrum of rare genetic disorders that can present with inflammatory bowel disease (IBD). My primary interest is to understand the role of bacteria-induced autophagy in macrophages by employing techniques such as culture techniques, confocal microscopy, FACS, or phospho-proteomics.
The presence of ~1014 gut microbiota makes it a challenging job for the host innate immune system to maintain gut homeostasis and macrophages are at the forefront of the immune system in the gut. Hundreds of proteins are involved in the handling of bacteria in macrophages and genetic mutations in these proteins can lead to severe gut inflammation. Understanding the diverse mechanisms how autophagy can be disturbed in monogenic diseases and thereby predispose to intestinal inflammation can serve as a translational platform for potential therapeutic approaches for patients with those rare disorders as well as for patients with Crohn’s disease or ulcerative colitis.
Q: What do you enjoy the most about working in science?
For me the most amazing thing in science is to understand the enormous complexity of biological phenomena. Being a microbiologist and biochemist, it is interesting to study how bacteria can survive within the host and modulate host physiology. Examining the molecular mechanisms of these host microbe interactions and designing experiments how to influence those mechanisms to protect the host is fun and a way to contribute to the society for better life.
News & Events
- Blenheim Fun Run 2017
- Curiosity Carnival
- International Clinical Trials Day, May 20th 2017
- The TGU welcomes STEM Apprentice Placements this summer!
- Oxford IBD MasterClass 2017
- Oxford IBD Masterclass 2016
- TGU at the Oxfordshire Science Festival
- A word from Prof. Paul Klenerman, the new Sidney Truelove Professor of Gastroenterology
- TGU at the BBSRC Great British Bioscience Festival
- Members of the Powrie group publish in Nature an important new role of IL-33
- NDM Scientists at Royal Society summer exhibition
- TGU at the Royal Society Summer Science Exhibition 2014
- TGU at the Royal Society Summer Exhibition
- BRC3 Gastro RMF Application form
- Clinician-Scientists in the making visit the TGU from the Chinese University of Hong Kong
- Launch event: Human Iron Research at Oxford (HIRO)
- Detailed map of colon cells in health and disease
- New grant to study the role of immune cells in lung regeneration
- NDM's Translational Gastroenterology Unit awarded a CRUK Primer grant of £100,000
- NDM Researchers elected Fellows of the Academy of Medical Sciences
- Oxford IBD Masterclass 2020
- Oxfordshire Research League Tables
- Memorial Service - Professor Satish Keshav
- Open Evening Crohn's and Colitis
- Tackling inflammatory bowel disease
- Human Immune Discovery Initiative (HIDI)
- The Good Doctors Guide: Meet the best doctors for gall bladder and learn the cutting-edge treatments for inflammatory bowel disease
- forCrohn's Heroes 2018
- TGU Awards, Grants and Prizes Sep-Oct 2016
- BRC - How Vital Funding Makes a Difference
- Falk Foundation Symposium - 29-30 Mar 2019
- Dietary Fibre Metabolite Helps Immune System Fight Invasive Bacteria
- Professor Satish Keshav
- High Sheriff Award
- FALK Symposium Poster First Prize Winner!
- TGU@10 - 10 Years Celebration Event!
- OUH Quality Improvement Symposium (QIP)
- TGU, University of Oxford Awarded the IBD Stress Test QuickFire Challenge
- Crohn's and Colitis Open Evening on Tuesday 4th February at 17.30-19.30
- OUH NURSE WINS NATIONAL AWARD
- Crohn's Disease and Ulcerative Colitis - Public Information Event April 2021
- Oxford IBD MasterClass 2022
- The Changing Face of Inflammatory Bowel Disease- Progress in Research and Clinical Care
- Oxford IBD MasterClass 2024 – Personalising care in IBD
- Please join us for our TGU@14 Symposium on Monday 11th September 2023 at St Anne’s College, Oxford.
- Shortlist Announced for Staff Awards
- NIHR Senior Research Fellows Awards
- Translational Gastroenterology Unit – Logo and Name Update
- TGU Biobank/IBD Cohort
- Training Opportunities
- TGU Podcasts
- Links for TGU Members
- Meet the Team
- Oxford IBD MasterClass 2024