October 2016: Malcolm Tan is a member of the Keshav Group and a medical professional.
How did you become interested in translational gastroenterology? By accident really! I arrived in Oxford as a clinician with the intention of learning the clinical aspects of managing IBD patients.
What surprised me was the laboratory, within throwing distance of the wards, which truly epitomises the phrase 'bench-to-bedside". With little background in laboratory work, Prof Keshav offered the opportunity pick up techniques in immunohistochemistry as part of a bigger study of lymphocyte activation gene (LAG-3) expression in ulcerative colitis, which I readily accepted as it was something that could not be passed on.
Q: What are you currently working on and what importance does your work hold for current patients with gastrointestinal issues?
Even with recent advances, there remains an unmet need for patients who are not responsive to current treatment options. New therapeutic targets need to be identified before novel biological agents can be tested.
LAG-3 is a CD-4 related protein found in activated T-cells and prolonged activation leads to chronic inflammation. Therefore, it is a potential therapeutic target in patients with IBD. Our group is looking at LAG-3 in the context of ulcerative colitis and together with Prof Keshav and Stephanie Slevin, we are interested in its differential expression in patients with acute colitis and treated colitis.
Q: What do you enjoy most about scientific research?
The process from ignorance to the excitement that comes with results. Ignorance, when coupled with the restlessness of uncertainty, spurs endeavours to answer scientific questions. The satisfaction from finding answers to the question is always welcome.
Q: What's the best part of being an Oxford University TGU member?
The once-in-a-lifetime opportunity to see the full spectrum of IBD, looking at how researchers from diverse backgrounds collaborate in the laboratory, the wards and the endoscopy suite to seek solutions for our patients. And Monday night football sessions with people from the TGU!
News & Events
- Blenheim Fun Run 2017
- Curiosity Carnival
- International Clinical Trials Day, May 20th 2017
- The TGU welcomes STEM Apprentice Placements this summer!
- Oxford IBD MasterClass 2017
- Oxford IBD Masterclass 2016
- TGU at the Oxfordshire Science Festival
- A word from Prof. Paul Klenerman, the new Sidney Truelove Professor of Gastroenterology
- TGU at the BBSRC Great British Bioscience Festival
- Members of the Powrie group publish in Nature an important new role of IL-33
- NDM Scientists at Royal Society summer exhibition
- TGU at the Royal Society Summer Science Exhibition 2014
- TGU at the Royal Society Summer Exhibition
- BRC3 Gastro RMF Application form
- Clinician-Scientists in the making visit the TGU from the Chinese University of Hong Kong
- Launch event: Human Iron Research at Oxford (HIRO)
- Detailed map of colon cells in health and disease
- New grant to study the role of immune cells in lung regeneration
- NDM's Translational Gastroenterology Unit awarded a CRUK Primer grant of £100,000
- NDM Researchers elected Fellows of the Academy of Medical Sciences
- Oxford IBD Masterclass 2020
- Oxfordshire Research League Tables
- Memorial Service - Professor Satish Keshav
- Open Evening Crohn's and Colitis
- Tackling inflammatory bowel disease
- Human Immune Discovery Initiative (HIDI)
- The Good Doctors Guide: Meet the best doctors for gall bladder and learn the cutting-edge treatments for inflammatory bowel disease
- forCrohn's Heroes 2018
- TGU Awards, Grants and Prizes Sep-Oct 2016
- BRC - How Vital Funding Makes a Difference
- Falk Foundation Symposium - 29-30 Mar 2019
- Dietary Fibre Metabolite Helps Immune System Fight Invasive Bacteria
- Professor Satish Keshav
- High Sheriff Award
- FALK Symposium Poster First Prize Winner!
- TGU@10 - 10 Years Celebration Event!
- OUH Quality Improvement Symposium (QIP)
- TGU, University of Oxford Awarded the IBD Stress Test QuickFire Challenge
- Crohn's and Colitis Open Evening on Tuesday 4th February at 17.30-19.30
- OUH NURSE WINS NATIONAL AWARD
- Crohn's Disease and Ulcerative Colitis - Public Information Event April 2021
- Oxford IBD MasterClass 2022
- The Changing Face of Inflammatory Bowel Disease- Progress in Research and Clinical Care
- Oxford IBD MasterClass 2024 – Personalising care in IBD
- Please join us for our TGU@14 Symposium on Monday 11th September 2023 at St Anne’s College, Oxford.
- Shortlist Announced for Staff Awards
- NIHR Senior Research Fellows Awards
- Translational Gastroenterology Unit – Logo and Name Update
- TGU Biobank/IBD Cohort
- Training Opportunities
- TGU Podcasts
- Links for TGU Members
- Meet the Team
- Oxford IBD MasterClass 2024