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Scientist working in lab

A research endoscopy facility is being commissioned (2012), with confocal endomicroscopy (established 2011) and evaluation of novel spectral imaging, especially comparing their value in assessment of inflammatory activity as much as the detection of dysplasia. This is lead by James East, assisted by consultants with an interest in endoscopy (Barbara Braden, Adam Bailey) and collaborating with the IBD specialists (Simon Travis, Satish Keshav, Alison Simmons). Current projects target early diagnosis of epithelial dysplasia in Barrett’s oesophagus using advanced imaging techniques (chromoendoscopy and narrow band imaging, as well as the refinement of staging techniques) and innovative therapeutic endoscopy for treating early malignancy in Barrett’s. Oxford is the UK lead for an international study evaluating endoscopic ultrasound for differentiting between inflammatory and neoplastic pancreatic cysts.

Other projects include:

  • Advanced endoscopy: UCEIS with NBI, confocal, dye-spray (how normal is normal?)
  • Confocal endoscopy to evaluate antibody binding ex-vivo
  • SPECTACLE chromo and confocal versus AFI/NBI for lesion detection (collaborating with Amsterdam Medical Center)
  • Sessile serrated polyp characterisation study (collaborating with AMC)
  • NBI video characterisation study (with Kansas VA group)
  • ESD complications and outcomes study (with Kobe University Hospital)
  • Endoscopic computer aided diagnosis for NBI polyp images (with Imperial/St Mark’s)