Fundamental and Translational Research

Research within the Translational Gastroenterology Unit involves fundamental research on cellular and molecular pathways of innate and adaptive immunity in the intestine, inflammation, and immune system-bacteria interactions. Scientific findings are applied to the study of gastrointestinal diseases including inflammatory bowel disease, chronic liver disease, and cancer. In conjunction with the careful study of clinically and genetically defined patient cohorts, these efforts help identify novel therapeutic strategies and methods for optimising current treatment protocols.

Principal Investigators (alphabetical order)

carolina arancibia

Dr. Carolina Arancibia

Translational Medicine, Lead
Mucosal Immunology

Prof. Simon Leedham

Adult gastrointestinal stem cells and role in colorectal cancer


Prof. Ellie Barnes

Experimental Medicine in liver disease, immunology, vaccines and hepatitis.

Kevin Maloy

Dr. Kevin Maloy

Host-pathogen interactions in the intestine


Dr. Elizabeth Bird-Lieberman

Upper Gastrointestinal Tract

philippa mathews

Dr. Philippa Matthews

Immunology, HBV infection

Oliver Brain

Dr. Oliver Brain



Prof. Fiona Powrie

Immunology of IBD and colorectal cancer

Jeremy Cobbold

Dr. Jeremy Cobbold

Gastroenterology, Hepatology


Prof. Jack Satsangi

Genetics, Genomics, Immunology & Infectious Disease

James East

Dr. James East

Cellular immunology, In vivo imaging, SNP typing


Prof. Alison Simmons

Molecular mechanisms of innate immunity and pathogen sensing

Alessandra Geremia

Dr. Alessandra Geremia

Academic Clinical Lecturer

simon travis

Prof. Simon Travis, FRCP

Drug discovery and In Vivo Imaging


Prof. Satish Keshav

Translational research in gastrointestinal immunology

holm thumb

Prof. Holm Uhlig

Paediatric gastroenterology and mucosal immunology

PK July 2019

Prof. Paul Klenerman

Antiviral immunity and hepatology

Alissa Walsh

Dr Alissa Walsh

Digital health, Remote monitoring of chronic disease