Prof Timothy SC Hinks
Contact information
+44 1865 (2)20885
Rachel Russell-Sharp
rachel.russell-sharp@ndm.ox.ac.uk
https://orcid.org/0000-0003-0699-2373
Room 7400A, Level 7 NDM, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
Research groups
The Hinks Lab
The Oxford severe asthma MDT and research nurse team
Collaborators
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Paul Klenerman
Sidney Truelove Professor of Gastroenterology
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Ian Pavord
Professor of Respiratory Medicine
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Lucy Garner
DPhil Student
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Teresa Street
Senior Postdoctoral Scientist
EXTERNAL COLLABORATORS
We collaborate with a number of groups across UK, Europe and worldwide including:
-Sally Cowley, Oxford Stem Cell Institute, Oxford
-Franze Progatzke, Kennedy Institute of Rheumatology, Oxford
-Julian Knight, Centre for Human Genomics, Oxford
-Peter Bradding, NIHR Leicester Respiratory BRC, UK
-Rachel Clifford, NIHR Nottingham Respiratory BRC, UK
-Peter Howarth, NIHR Southampton Respiratory BRC, UK
-Mustafa Abdo, Deutsches Zentrum für Lungenforschung, Germany
-Theodoros Kapellos, Helmholtz Munich, Germany
-Alexandra Corbett, University of Melbourne, Australia
-David Choy, Genentech, USA
Prof Timothy SC Hinks
BMBCh MA (Cantab) MRCP PhD
Wellcome Trust Fellow & Honorary Consultant
- Associate Professor and Wellcome Trust Career Development Fellow, Respiratory Immunology, Nuffield Dept of Medicine
- NIHR Oxford Biomedical Research Centre Senior Research Fellow
- Honorary Consultant, Oxford Special Airway Service, Respiratory Medicine, Oxford University Hospitals NHS Trust
Investigating immune responses in asthma and lung infections
Research Interests
My group investigate the immunopathogenesis of airway diseases and pulmonary infections. We have a specific focus on the roles of unconventional T cells subsets in the mucosal immunology of the airways in driving inflammation during chronic airways infection, and gene expression and epigenomics of specific asthma phenotypes.
After a background in translational research in T cell immunodiagnostics in tuberculosis I have been funded by fellowships from the Wellcome Trust, Academy of Medical Sciences and National Institute of Health Research to study novel T cell subsets in the airways in human asthma and more recently the roles of mucosal associated invariant T (MAIT) cells in ex vivo and murine models of infection with Haemophilus influenzae, Legionella and Influenza virus. Our recent work has defined novel functions for MAIT cells in tissue repair, identified mechanisms of macrolides in airways diseases and generated a new two-compartment model of asthma pathology.
Our goal is to apply single cell, spatial and classical immunological approaches to better understand the immunopathogenesis of asthma, to help develop new therapies.
Funding
Research groups
Current positions
Postdoctoral Scientist
Currently we have a position open for a postdoc - focusing on defining the mechanisms by which bacteria subvert mucosal immunity to establish a niche within the airways. If you are interested, please get in touch by email to find out more.
Innate T cells in airways disease
Pulmonary spatial transcriptomics
Websites
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Volunteer as a research participant
If you would be interested in volunteering in our research studies, either as a healthy control or as someone with asthma, fill in this form and we can tell you more
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Our research bronchoscopies
Find out what its like to volunteer for one of our research bronchoscopy studies
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Bronchoscopies explained
The full length video - watch research volunteer Tom undergo a bronschoscopy
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Severely asthma - Peter's story
Listen to Peter's experience of living with severe asthma, and the transformative effects of new treatments
Recent publications
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Anti-inflammatory effects of oral prednisolone at stable state in people treated with mepolizumab: a proteomic and bulk transcriptomics analysis
Preprint
Howell I. et al, (2024)
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MAIT cells protect against sterile lung injury
Preprint
Zhang X. et al, (2024)
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The effects of inhaled corticosteroids on healthy airways
Preprint
Marchi E. et al, (2023)
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Recovery of Breakthrough Asthma Attacks Treated With Oral Steroids While on Monoclonal Antibody Therapy: Protocol for a Prospective Observational Study (BOOST)
Journal article
Howell I. et al, (2023), JMIR Research Protocols, 12, e46741 - e46741
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An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity.
Journal article
Wing PAC. et al, (2023), PLoS pathogens, 19