We collaborate with a number of groups across UK, Europe and worldwide including:

-Sally Cowley, Oxford Stem Cell Institute, Oxford

-Franze Progatzke, Kennedy Institute of Rheumatology, Oxford

-Julian Knight, Centre for Human Genomics, Oxford

-Peter Bradding, NIHR Leicester Respiratory BRC, UK

-Rachel Clifford, NIHR Nottingham Respiratory BRC, UK

-Peter Howarth, NIHR Southampton Respiratory BRC, UK

-Mustafa Abdo, Deutsches Zentrum für Lungenforschung, Germany

-Theodoros Kapellos, Helmholtz Munich, Germany

-Alexandra Corbett, University of Melbourne, Australia

-David Choy, Genentech, USA

My group investigate the immunopathogenesis of airway diseases and pulmonary infections. We have a specific focus on the roles of unconventional T cells subsets in the mucosal immunology of the airways in driving inflammation during chronic airways infection, and gene expression and epigenomics of specific asthma phenotypes.

After a background in translational research in T cell immunodiagnostics in tuberculosis I have been funded by fellowships from the Wellcome Trust, Academy of Medical Sciences and National Institute of Health Research to study novel T cell subsets in the airways in human asthma and more recently the roles of mucosal associated invariant T (MAIT) cells in ex vivo and murine models of infection with Haemophilus influenzae, Legionella and Influenza virus. Our recent work has defined novel functions for MAIT cells in tissue repair, identified mechanisms of macrolides in airways diseases and generated a new two-compartment model of asthma pathology. 

Our goal is to apply single cell, spatial and classical immunological approaches to better understand the immunopathogenesis of asthma, to help develop new therapies.

Postdoctoral Scientist

Currently we have a position open for a postdoc - focusing on defining the mechanisms by which bacteria subvert mucosal immunity to establish a niche within the airways. If you are interested, please get in touch by email to find out more.