Prof Timothy SC Hinks
The Hinks Lab
The Oxford severe asthma MDT and research nurse team
Prof Timothy SC Hinks
BMBCh MA (Cantab) MRCP PhD
Wellcome Trust Fellow & Honorary Consultant
- Associate Professor and Wellcome Trust Career Development Fellow, Respiratory Immunology, Nuffield Dept of Medicine
- NIHR Oxford Biomedical Research Centre Senior Research Fellow
- Honorary Consultant, Oxford Special Airway Service, Respiratory Medicine, Oxford University Hospitals NHS Trust
Investigating immune responses in asthma and lung infections
My group investigate the immunopathogenesis of airway diseases and pulmonary infections. We have a specific focus on the roles of unconventional T cells subsets in the mucosal immunology of the airways in driving inflammation during chronic airways infection, and gene expression and epigenomics of specific asthma phenotypes.
After a background in translational research in T cell immunodiagnostics in tuberculosis I have been funded by fellowships from the Wellcome Trust, Academy of Medical Sciences and National Institute of Health Research to study novel T cell subsets in the airways in human asthma and more recently the roles of mucosal associated invariant T (MAIT) cells in ex vivo and murine models of infection with Haemophilus influenzae, Legionella and Influenza virus. Our recent work has defined novel functions for MAIT cells in tissue repair, identified mechanisms of macrolides in airways diseases and generated a new two-compartment model of asthma pathology.
Our goal is to apply single cell, spatial and classical immunological approaches to better understand the immunopathogenesis of asthma, to help develop new therapies.
Currently we have a position open for a postdoc - focusing on defining the mechanisms by which bacteria subvert mucosal immunity to establish a niche within the airways. If you are interested, please get in touch by email to find out more.
Innate T cells in airways disease
Pulmonary spatial transcriptomics
MAIT cells protect against sterile lung injury
Zhang X. et al, (2024)
The effects of inhaled corticosteroids on healthy airways
Marchi E. et al, (2023)
Recovery of Breakthrough Asthma Attacks Treated With Oral Steroids While on Monoclonal Antibody Therapy: Protocol for a Prospective Observational Study (BOOST)
Howell I. et al, (2023), JMIR Research Protocols, 12, e46741 - e46741
An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity.
Wing PAC. et al, (2023), PLoS pathogens, 19
Epithelial immune activation and intracellular invasion by non-typeable Haemophilus influenzae
Brown MA. et al, (2023), Frontiers in Cellular and Infection Microbiology, 13