Dr Timothy SC Hinks
Contact information
+44 1865 (2)21913
https://orcid.org/0000-0003-0699-2373
Room 7504, Level 7 NDM, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
Research groups
The Oxford severe asthma MDT and research nurse team
Colleges
Dr Timothy SC Hinks
BMBCh MA (Cantab) MRCP PhD
Wellcome Trust Fellow & Honorary Consultant
- Wellcome Trust Career Development Fellow, Respiratory Immunology, Nuffield Dept of Medicine
- NIHR Oxford Biomedical Research Centre Senior Research Fellow
- Honorary Consultant, Oxford Special Airway Service, Respiratory Medicine, Oxford University Hospitals NHS Trust
- Todd-Bird Fellow in Clinical Medicine, New College, Oxford
Investigating immune responses in asthma and lung infections
Research Interests
My group investigate the immunopathogenesis of airway diseases and pulmonary infections. We have a specific focus on the roles of novel T cell subsets in the mucosal immunology of the airways, particularly in driving inflammation in asthma and during chronic airways infection.
After a background in translational research in T cell immunodiagnostics in tuberculosis I have been funded by fellowships from the Wellcome Trust, Academy of Medical Sciences and National Institute of Health Research to study novel T cell subsets in the airways in human asthma and more recently the roles of mucosal associated invariant T (MAIT) cells in ex vivo and murine models of infection with Haemophilus influenzae, Legionella and Influenza virus.
Our goal is to better understand the immune responses which protect us from lung infections or can drive airways inflammation, to help develop new treatments to prevent exacerbations of lung diseases and to accelerate the development of improved vaccines.
Funding
Innate T cells in airways disease
Websites
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The ATOMIC2 Trial
The HinksLab are leading this clinical trial of azithromycin in COVID-19
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Bronchoscopy procedure
Watch research volunteer Tom undergo a bronschoscopy
Recent publications
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In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control
Journal article
Ansari MA. et al, (2021), Wellcome Open Research, 6, 47 - 47
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MAIT cell activation augments adenovirus vector vaccine immunogenicity
Journal article
Provine NM. et al, (2021), Science, 371, 521 - 526
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Reply to Lipworth et al.: Don’t Forget about Facilitatory Effects of Corticosteroids on β2-Adrenoceptors in Acute Asthma
Journal article
Moran AM. et al, (2020), American Journal of Respiratory and Critical Care Medicine, 202, 1743 - 1744
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Depletion rate of blood eosinophils with mepolizumab, benralizumab and oral prednisolone in patients with severe asthma
Conference paper
Moran A. et al, (2020), EUROPEAN RESPIRATORY JOURNAL, 56
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Boosting MAIT cells as immunotherapy: context is everything
Journal article
Hinks TSC., (2020), Mucosal Immunology