Dr Timothy SC Hinks
The Oxford severe asthma MDT and research nurse team
Dr Timothy SC Hinks
BMBCh MA (Cantab) MRCP PhD
Wellcome Trust Fellow & Honorary Consultant
- Wellcome Trust Career Development Fellow, Respiratory Immunology, Nuffield Dept of Medicine
- NIHR Oxford Biomedical Research Centre Senior Research Fellow
- Honorary Consultant, Oxford Special Airway Service, Respiratory Medicine, Oxford University Hospitals NHS Trust
- Todd-Bird Fellow in Clinical Medicine, New College, Oxford
Investigating immune responses in asthma and lung infections
My group investigate the immunopathogenesis of airway diseases and pulmonary infections. We have a specific focus on the roles of novel T cell subsets in the mucosal immunology of the airways, particularly in driving inflammation in asthma and during chronic airways infection.
After a background in translational research in T cell immunodiagnostics in tuberculosis I have been funded by fellowships from the Wellcome Trust, Academy of Medical Sciences and National Institute of Health Research to study novel T cell subsets in the airways in human asthma and more recently the roles of mucosal associated invariant T (MAIT) cells in ex vivo and murine models of infection with Haemophilus influenzae, Legionella and Influenza virus.
Our goal is to better understand the immune responses which protect us from lung infections or can drive airways inflammation, to help develop new treatments to prevent exacerbations of lung diseases and to accelerate the development of improved vaccines.
Innate T cells in airways disease
In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control
Ansari MA. et al, (2021), Wellcome Open Research, 6, 47 - 47
MAIT cell activation augments adenovirus vector vaccine immunogenicity
Provine NM. et al, (2021), Science, 371, 521 - 526
Reply to Lipworth et al.: Don’t Forget about Facilitatory Effects of Corticosteroids on β2-Adrenoceptors in Acute Asthma
Moran AM. et al, (2020), American Journal of Respiratory and Critical Care Medicine, 202, 1743 - 1744
Depletion rate of blood eosinophils with mepolizumab, benralizumab and oral prednisolone in patients with severe asthma
Moran A. et al, (2020), EUROPEAN RESPIRATORY JOURNAL, 56
Boosting MAIT cells as immunotherapy: context is everything
Hinks TSC., (2020), Mucosal Immunology