Consultant in Infection (Oxford University Hospitals NHS Foundation Trust), NIHR Oxford Senior Research Fellow, Oxford Martin School Fellow
I work as a Consultant in infectious diseases and medical microbiology at the John Radcliffe Hospital in Oxford and also run a portfolio of research studies investigating various aspects of: (i) antimicrobial resistance (AMR), particularly in Enterobacterales; (ii) One Health and AMR gene dissemination/pathogen spillover across reservoirs; (iii) rapid diagnostics, including projects on nanoimaging, antigen/antibody tests, and pathogen sequencing, including DNA and RNA sequencing of isolates, and metagenomic sequencing of clinical samples; and (iv) epidemiology of infectious diseases more broadly, including SARS-CoV-2.
I am currently co-supervising four DPhil students and am a member of the Leadership Committee of the Medical Research Foundation's National PhD Training Programme in AMR Research (https://amrtraining.ac.uk/) - a highly interdisciplinary programme specifically designed to incorporate multi-disciplinarity in AMR research.
I am very active in grant and peer review, am on the editorial board of Antimicrobial Agents and Chemotherapy, and support my students in their roles on Microbial Genomics' Early Career Board of Reviewers. I am also strongly supportive of patient and public involvement and engagement (PPIE) in research, having most recently developed a hands-on community programme structured around theatre in educating children and their caregivers about microbes, infections and AMR.
Mortality risks associated with empirical antibiotic activity in Escherichia coli bacteraemia: an analysis of electronic health records.
Yoon CH. et al, (2022), J Antimicrob Chemother
Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales.
Marimuthu K. et al, (2022), Nature communications, 13
Comparison of R9.4.1/Kit10 and R10/Kit12 Oxford Nanopore flowcells and chemistries in bacterial genome reconstruction
Sanderson N. et al, (2022)
An Observational Cohort Study on the Incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and B.1.1.7 Variant Infection in Healthcare Workers by Antibody and Vaccination Status
Lumley SF. et al, (2022), Clinical Infectious Diseases, 74, 1208 - 1219
Hospital outbreak of carbapenem-resistant Enterobacterales associated with a bla OXA-48 plasmid carried mostly by Escherichia coli ST399.
Ledda A. et al, (2022), Microbial genomics, 8