Kate Dingle
Contact information
Research groups
Kate Dingle
Postdoctoral Scientist
Research
Kate is a senior scientist (molecular biology) working with the Modernising Medical Microbiology team in the Nuffield Department of Clinical Medicine. Her current research focus is the development of molecular methods exploiting whole genome sequencing for the rapid diagnosis of Mycobacteria infections. She is also investigating the role of antimicrobial resistance in the emergence of clinically important Clostridium difficile strains infecting humans.
Kate completed her PhD in 1995 at Southampton University, determining the first complete genome sequence of a Genogroup II Norovirus. After a few years as a post-doc at Fox Chase Cancer Centre, Philadelphia (USA), she moved to Oxford, joining a team using DNA sequences to study Campylobacter molecular epidemiology. Kate joined the research group at the John Radcliffe Hospital in 2002, where she has continued to use nucleotide sequence data to study the epidemiology and evolution of pathogens including Campylobacter jejuni and C. coli, Clostridium difficile and Norovirus. In parallel with this work, Kate has used her molecular biology background to develop molecular diagnostic assays for pathogens including common respiratory viruses.
Key publications
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Clostridium difficile trehalose metabolism variants are common and not associated with adverse patient outcomes when variably present in the same lineage
EYRE D. et al, EBioMedicine
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A role for tetracycline selection in the evolution of Clostridium difficile PCR-ribotype 078
Dingle KE. et al, (2018)
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Effects of control interventions on Clostridium difficile infection in England: an observational study
Dingle KE. et al, (2017), The Lancet Infectious Diseases, 17, 411 - 421
Recent publications
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Evaluation of sequence hybridization for respiratory viruses using the Twist Bioscience Respiratory Virus Research panel and the OneCodex Respiratory Virus sequence analysis workflow
Kapel N. et al, (2023), Microbial Genomics, 9
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Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile
Dingle KE. et al, (2023), mBio, 14
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Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination, and Drug Susceptibility Prediction
Nilgiriwala K. et al, (2023), Journal of Clinical Microbiology, 61
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Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination and Drug Susceptibility Prediction
Nilgiriwala K. et al, (2022)
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Modern Solutions for Ancient Pathogens: Direct Pathogen Sequencing for Diagnosis of Lepromatous Leprosy and Cerebral Coenurosis
Young BC. et al, (2022), Open Forum Infectious Diseases, 9