Dingle KE., Freeman J., Didelot X., Quan TP., Eyre DW., Swann J., Spittal WD., Clark EV., Jolley KA., Walker AS., Wilcox MH., Crook DW.

Fluoroquinolone and cephalosporin use in healthcare settings has triggered outbreaks of high-mortality, multidrug-resistant C. difficile infection. Here, we identify a mechanism associated with raised cephalosporin MICs in C. difficile comprising amino acid substitutions in two cell wall transpeptidase enzymes (penicillin binding proteins).

Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile

Dingle KE., Freeman J., Didelot X., Quan TP., Eyre DW., Swann J., Spittal WD., Clark EV., Jolley KA., Walker AS., Wilcox MH., Crook DW.

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