Ross Sadler is a Consultant Clinical Scientist and Clinical Lead for Laboratory Immunology. Ross and the Immunology laboratory has collaborated with the Gastroenterology department since the beginning of the IgG4-related disease patient cohort study. Primarily, the Immunology laboratory produces the Immunoglobulin measurements (Total IgG, IgG1-IgG4 and IgE) for patient diagnosis and management. We have worked with members of the study team to explore other methods of investigation of patients with suspected IgG4-related disease such as B cell ELI-Spot and flow cytometry. We continue to try and determine what new analytical markers prove useful in diagnosing and managing these patients as well as shed light on the aetiology and pathogenesis.