MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headington OX3 9DS
Interview: Immune responses in lung disease - Sarcoidosis
DPhil, FRCP, MD
Professor of Respiratory Immunology
We are interested in how immunological responses impact on mechanisms of lung injury and repair. The projects are divided into mechanistic and translational studies. The mechanistic studies question how innate immune cells like iNKT cells, MDSCs and monocyte-macrophage lineage impact on outcome in severe influenza virus infection and progression of lung fibrosis. These studies inform, drive and allow us to test mechanistic hypotheses in/from our human work.
In the translational space, our focus is on new or improved therapy for lung fibrosis. Our diseases of interest are idiopathic pulmonary fibrosis (IPF) and fibrotic sarcoidosis, and we target the interface between cellular immunology, disease mechanisms and early clinical trials.
Current projects in the group
- Role of epithelial CD1d in local lung immune homeostasis and responses
- Impact of monocyte subtypes, monocyte-derived macrophages and MDSCs on immune response to pathogens
- Development of human lung organoid models for idiopathic pulmonary fibrosis
- Contribution of monocyte-macrophage subtypes to acceleration and acute exacerbations of idiopathic pulmonary fibrosis
- Examination of M-CSF/CSF-1R pathway as a potential therapy for IPF
Note: for Clinical Respiratory Specialist inquiries, Prof Ho's address is
Interstitial Lung Disease Service
Oxford Center for Respiratory Medicine
Churchill Hospital, Oxford OX3 7LJ
COVID-19 therapeutics: Challenges and directions for the future.
Robinson PC. et al, (2022), Proceedings of the National Academy of Sciences of the United States of America, 119
Monocyte and neutrophil levels are potentially linked to progression to IPF for patients with indeterminate UIP CT pattern
Achaiah A. et al, (2021)
Longitudinal COVID-19 profiling associates IL-1Ra and IL-10 with disease severity and RANTES with mild disease.
Zhao Y. et al, (2020), JCI insight
Sarcoidosis in the UK: insights from British Thoracic Society registry data.
Thillai M. et al, (2019), BMJ Open Respir Res, 6
A READILY ACCESSIBLE CT-BASED SCORE TO MEASURE AMOUNT OF FIBROSIS IN IPF
Fraser E. et al, (2018), THORAX, 73, A46 - A46
How the Respiratory Epithelium Senses and Reacts to Influenza Virus.
Benam KH. et al, (2018), Am J Respir Cell Mol Biol
Development of a best-practice clinical guideline for the use of bleomycin in the treatment of germ cell tumours in the UK.
Watson RA. et al, (2018), Br J Cancer, 119, 1044 - 1051