David Smith
Postdoctoral Scientist
Brief Biography:
I joined the Barnes group in 2014 to work on the National Institute for Health Research Health Informatics Collaborative (NIHR HIC) Viral Hepatitis Theme, this project focused on the collation of routinely collected clinical data from NHS trusts and its use for clinical research.
I started a DPhil in 2015, I used next generation sequencing and cell culture models to study anti-viral resistance to Hepatitis C Infection. The focus of this project is on genotype 3 infection, which is the second most common genotype in the UK and is emerging as the hardest HCV genotype to treat.
Since completing my DPhil, I have expanded on my DPhil work which used viral genome wide association studies to identify novel resistance associated substitutions against HCV anti-virals. I have also been working on using the data collected from the NIHR HIC project to understand Hepatitis B Virus S antigen clearance and to understand the prognostic value of liver biochemistry in patients with severe COVID-19.
Recent publications
-
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Preprint
Campbell C. et al, (2024)
-
Cohort Profile: The National Institute for Health Research Health Informatics Collaborative: Hepatitis B Virus (NIHR HIC HBV) research dataset
Journal article
Wang T. et al, (2023), International Journal of Epidemiology, 52, e27 - e37
-
An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression
Journal article
Cano-Gamez E. et al, (2022), Science Translational Medicine, 14
-
Identifying Hepatocellular Carcinoma from imaging reports using natural language processing to facilitate data extraction from electronic patient records
Preprint
Wang T. et al, (2022)
-
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK
Preprint
Campbell C. et al, (2022)