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NEKSUS

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Leads: Nicole Stoesser (University of Oxford) and Samuel Lipworth (University of Oxford)

National Escherichia coli and KlebSiella Bloodstream Infection and Carbapenemase-Producing Enterobacterales UK Surveillance Study aims to provide additional genomic characterisation of bloodstream infection (BSI) isolates reported by NHS laboratories as part of the existing UKHSA mandatory surveillance programme. Genomic data will be combined with epidemiological and microbiological data to inform optimal sampling frames and bioinformatic processes for the development of a national genomic surveillance system for Gram-negative BSIs. Collecting this type of genomic data may help tackle the growing burden of antibiotic-resistant Gram-negative BSIs in England by enabling the tracking of BSI-associated mobile genetic elements such as plasmids, including those that transmit major drug resistance mechanisms of concern such as carbapenemase genes.  

The NEKSUS Consortium consists of investigators from the microbiological laboratories of nine acute NHS hospitals representing all seven NHS England regions, as well as collaborators from the UK Health Security Agency (UKHSA).