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Hepitopes

Click on for more information on Hepitopes databaseHepitopes is a project, funded by the Wellcome Trust, to collate all the existing HBV epitopes restricted by HLA Class I genes, and to develop this into a live on-line resource that can grow and develop over time.

The initial stage of this work has been to perform a literature search to identify all epitopes that have been published to date. We have undertaken a detailed review of all the references such that we can list epitope HLA-restrictions, locations in the HBV proteome, sequences and polymorphisms, and report preliminary data regarding the potential clinical significance of epitope-specific T cell immune responses.

Over time, this database will continue to be updated such that we can develop and maintain an open-access resource that is useful for basic research and clinical vaccine design. This will include new epitopes identified as a result of my own work in Hepatitis B immunogenetics, as well as continuing to identify and collate new epitopes published by other groups.

The Hepitopes Database was launched to make it available for the 2016 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses (21-24 September 2016). The poster presented at this meeting can be viewed on-line.

Please scroll down to visit the interactive database.

In this section

The Bio-medical Research Council (BRC), a part of the Oxford Hospital Radcliffe Trust (OHRT), funds research and many of our staff are involved in BRC research.

Our research is funded from a variety of funders. Their support allows our research to focus on the basic and clinical research domains to accelerate knowledge translation from the bedside to the bench, and back again.