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The overarching aim of ARK is to reduce the incidence of serious infections caused by antibiotic-resistant bacteria in the future, through substantially and safely reducing antibiotic use in hospitals now.


The specific research questions are:

  • how can antibiotic prescription ‘review&revise’ strategies be implemented optimally to reduce antibiotic use safely within hospitals?
  • can we build a feasible inexpensive package of interventions that increase prescriber compliance with ‘review&revise’, and patient acceptability of shorter antibiotic therapy durations driven by ‘review&revise’?
  • are ‘review&revise’ strategies cost-effective across a range of scenarios reflecting plausible associations between antibiotic use now and future resistance leading to loss of antibiotic options?