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Influenza viruses are an ongoing threat to humans and are endemic in pigs, causing considerable economic losses to farmers. Pigs are also a source of new viruses potentially capable of initiating human pandemics. Many tools including monoclonal antibodies, recombinant cytokines and chemokines, gene probes, tetramers, and inbred pigs allow refined analysis of immune responses against influenza. Recent advances in understanding of the pig innate system indicate that it shares many features with that of humans, although there is a larger gamma delta component. The fine specificity and mechanisms of cross-protective T cell immunity have yet to be fully defined, although it is clear that the local immune response is important. The repertoire of pig antibody response to influenza has not been thoroughly explored. Here we review current understanding of adaptive immune responses against influenza in pigs and the use of the pig as a model to study human disease.

Original publication

DOI

10.3389/fimmu.2019.00098

Type

Journal article

Journal

Frontiers in immunology

Publication Date

01/2019

Volume

10

Addresses

Department of Mucosal Immunology, The Pirbright Institute (BBSRC), Pirbright, United Kingdom.

Keywords

B-Lymphocytes, T-Lymphocytes, Animals, Swine, Humans, Orthomyxoviridae, Orthomyxoviridae Infections, Disease Models, Animal, Swine Diseases, Influenza, Human, Adaptive Immunity, Pandemics