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Knowledge of the epidemiology of invasive pneumococcal disease (IPD) will aid in planning the use of pneumococcal vaccines. A United Kingdom (UK)-based surveillance in England and Wales (1995-1997) of 11,528 individuals with IPD and a local enhanced surveillance in the Oxford (UK) area (1995-1999) have been analyzed. IPD has a high attack rate in children, with 37.1-48.1 cases per 100,000 infants <1 year old per year, and in older persons, with 21.2-36.2 cases per 100,000 persons >65 years old per year, for England, Wales, and Oxford. The 7-valent conjugate vaccine includes serotypes causing < or =79% of IPD in children <5 years old, but only 66% in adults >65 years old. The data also indicate that IPD varies by serotype, age, and country, emphasizing that the epidemiology of IPD is heterogeneous and requires continued surveillance.

Original publication




Journal article


J Infect Dis

Publication Date





239 - 246


Adolescent, Adult, Age Distribution, Aged, Anti-Bacterial Agents, Child, Child, Preschool, Drug Resistance, Microbial, England, Female, Humans, Incidence, Infant, Male, Microbial Sensitivity Tests, Middle Aged, Pneumococcal Infections, Pneumococcal Vaccines, Serotyping, Streptococcus pneumoniae, Vaccination, Vaccines, Conjugate, Wales