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X-linked hyper-IgM syndrome (X-HIM) is an immunodeficiency caused by mutations in the gene encoding the CD40 ligand (CD40L). A database (CD40Lbase) of CD40L mutations has now been established, and the resultant information, together with other mutations reported elsewhere in the literature, is presented here.


Journal article


Immunol Today

Publication Date





511 - 516


CD40 Antigens, CD40 Ligand, Databases, Factual, Genetic Linkage, Humans, Hypergammaglobulinemia, Immunoglobulin M, Ligands, Membrane Glycoproteins, Mutation, X Chromosome