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A randomized crossover study of prophylactic immunoglobulin (IgG) therapy was performed in patients with chronic lymphocytic leukaemia (CLL) or non-Hodgkin's lymphoma (NHL). Twelve patients with hypogammaglobulinemia or a history of recurrent infections received infusions of IgG or placebo intravenously (IV) every 3 weeks for 1 year. They were then switched to the alternative preparation for another year. The number of serious bacterial infections was significantly less (P = .001; Mainland's cross-over method) in the months in which patients received IgG. Serious bacterial infections showed a trend to be associated with an IgG level less than 6.4 g/L (P = .046; Fisher's exact test).


Journal article



Publication Date





366 - 368


Aged, B-Lymphocytes, Double-Blind Method, Humans, Immunization, Passive, Immunoglobulin G, Immunoglobulins, Intravenous, Infection, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Non-Hodgkin, Middle Aged, Prognosis, Random Allocation