Complete sequencing of plasmids containing blaOXA-163 and blaOXA-48 in Escherichia coli ST131.
Stoesser N., Sheppard AE., Peirano G., Sebra R., Lynch T., Anson L., Kasarskis A., Motyl MR., Crook DW., Pitout JD.
OXA-48-like enzymes have emerged as important extended-spectrum β-lactamases/carbapenemases in E. coli ST131. We report the structure of the first fully sequenced blaOXA-163 plasmid, and of two other blaOXA-48 plasmids in this lineage. blaOXA-163 was located on a 71kb IncN plasmid with other resistance genes. blaOXA-48 was present on IncL/M plasmids, genetically similar to other blaOXA-48 plasmid sequences, and consistent with inter-species/inter-lineage spread. The presence of blaOXA-48-like genes on epidemic plasmids in ST131 is of concern.