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Recent reports of hepatitis A virus (HAV) infection in haemophiliacs receiving high-purity solvent detergent (HP.SD) treated factor VIII concentrates have brought into question the efficacy of this virucidal method for inactivating HAV. To assess whether HAV may have been transmitted by HP.SD concentrates, we compared seroprevalence in haemophiliacs with different disease severity, sought evidence of seroconversion to HAV since introduction of HP.SD products, and directly examined concentrates for HAV RNA by PCR. Our data suggest that Scottish haemophiliacs are not being infected with HAV by HP.SD concentrates produced initially by CRTS Lille and presently by PFC Edinburgh and supplied by the Scottish National Blood Transfusion Service (SNBTS).


Journal article


Br J Haematol

Publication Date





214 - 216


Adolescent, Adult, Base Sequence, Child, Drug Contamination, Factor VIII, Hemophilia A, Hepatitis A, Hepatitis A Virus, Human, Humans, Male, Molecular Sequence Data, Organophosphates, Polymerase Chain Reaction, Polysorbates, Retrospective Studies