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Progressive systemic neurotoxicity is a common feature in patients envenomed following the bite of a Papuan taipan (Oxyuranus scutellatus canni). Respiratory paralysis, which commonly results, accounts for considerable morbidity and mortality. Established neurotoxicity does not respond to antivenom. In this study, a combination of clinical and electrophysiological variables was used to assess the effect of edrophonium and 3,4-diaminopyridine in patients with significant neurotoxicity. Both drugs produced minor electrophysiological and clinical changes in envenomed patients. This effect was maximal when the 2 drugs were used in combination, but was insufficient to be of significant clinical benefit. Neither drug can be recommended for use in the management of Papuan taipan bite.

Type

Journal article

Journal

Trans R Soc Trop Med Hyg

Publication Date

07/1995

Volume

89

Pages

444 - 446

Keywords

4-Aminopyridine, Action Potentials, Amifampridine, Animals, Antidotes, Atropine, Drug Combinations, Edrophonium, Elapid Venoms, Elapidae, Hand Strength, Humans, Snake Bites