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Neutralising antibody responses to six post-exposure regimens of human diploid cell strain rabies vaccine with or without human rabies immune globulin (HRIG) were studied in 98 patients. The total amount of vaccine used was 22-34% of that required by conventional regimens. Vaccine was given at multiple sites intradermally or subcutaneously with or without adjuvant. Antibody was detectable within 7 days of the first dose in all subjects only in the groups given 0.1 ml intradermally at 8 sites. From day 14 onwards all groups showed an excellent antibody response; there was little difference between the various regimens. Suppression of the response to 8-site intradermal vaccination by a large dose of HRIG could be prevented by giving the second dose of vaccine on day 7 rather than day 14.


Journal article



Publication Date





874 - 876


Adjuvants, Immunologic, Adolescent, Adult, Aged, Antibodies, Viral, Child, Costs and Cost Analysis, Female, Humans, Immunization, Passive, Injections, Intradermal, Injections, Subcutaneous, Male, Middle Aged, Rabies, Rabies Vaccines, Time Factors, Vaccination