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Neutralising antibody responses to six post-exposure regimens of human diploid cell strain rabies vaccine with or without human rabies immune globulin (HRIG) were studied in 98 patients. The total amount of vaccine used was 22-34% of that required by conventional regimens. Vaccine was given at multiple sites intradermally or subcutaneously with or without adjuvant. Antibody was detectable within 7 days of the first dose in all subjects only in the groups given 0.1 ml intradermally at 8 sites. From day 14 onwards all groups showed an excellent antibody response; there was little difference between the various regimens. Suppression of the response to 8-site intradermal vaccination by a large dose of HRIG could be prevented by giving the second dose of vaccine on day 7 rather than day 14.

Type

Journal article

Journal

Lancet

Publication Date

21/04/1984

Volume

1

Pages

874 - 876

Keywords

Adjuvants, Immunologic, Adolescent, Adult, Aged, Antibodies, Viral, Child, Costs and Cost Analysis, Female, Humans, Immunization, Passive, Injections, Intradermal, Injections, Subcutaneous, Male, Middle Aged, Rabies, Rabies Vaccines, Time Factors, Vaccination