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Seven patients in acute exacerbation of chronic respiratory failure were given 24.5% and later 28% oxygen through Ventimasks. The mean increases in arterial PO(2) were 11 and 21 mm. Hg while breathing 24.5% and 28% oxygen respectively compared with control values while breathing air. Associated increases in arterial PCO(2) were 4 and 8 mm. Hg, respectively. In five of the patients these increases in inspired oxygen concentration resulted in useful increases in tissue oxygen supply without significant deterioration in ventilation, but in two patients arterial PCO(2) rose excessively and artificial ventilation was required.

Type

Journal article

Journal

Br Med J

Publication Date

23/05/1970

Volume

1

Pages

452 - 455

Keywords

Aged, Arteries, Blood Urea Nitrogen, Carbon Dioxide, Chlorides, Electrocardiography, Female, Hemoglobinometry, Humans, L-Lactate Dehydrogenase, Lactates, Leukocyte Count, Male, Middle Aged, Oxygen, Oxygen Inhalation Therapy, Potassium, Respiratory Insufficiency, Sodium, Spirometry