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The effects of isoprenaline and salbutamol administered orally, by inhalation, or by intravenous infusion were compared in 13 asthmatic patients. Bronchodilator activity was assessed by serial measurement of specific airways conductance (SGaw). Log-dose response curves were obtained for both drugs and showed them to be equipotent as bronchodilators. Cardiovascular effects were variable, but in general, isopenaline caused greater rise in pulse rate and a greater change in blood pressure than the same dose of salbutamol.Cardiorespiratory measurements during continuous intravenous infusion of increasing doses of both drugs suggested a greater effect of isoprenaline than the same dose of salbutamol on metabolic rate, pulmonary ventilation, pulmonary gas exchange, cardiac output, and heart rate. The effect of salbutamol on the heart rate was about 10 times less than that of isoprenaline but lasted longer.

Type

Journal article

Journal

Br Med J

Publication Date

10/01/1970

Volume

1

Pages

65 - 70

Keywords

Adult, Aged, Alcohols, Asthma, Blood Pressure, Bronchodilator Agents, Cardiac Output, Female, Heart, Heart Rate, Humans, Isoproterenol, Male, Middle Aged, Pulse, Respiration