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<jats:title>Abstract</jats:title><jats:sec id="S0022215115000195_sec1"><jats:title>Background:</jats:title><jats:p>ENT surgeons may be the first specialists to encounter and diagnose patients with salivary gland disease. A new entity involving the salivary glands has recently been described of which ENT surgeons need to be aware: immunoglobulin G4 related chronic sclerosing sialadenitis.</jats:p></jats:sec><jats:sec id="S0022215115000195_sec2"><jats:title>Method:</jats:title><jats:p>A literature search of Medline, Embase and Cochrane Library databases was performed, using the search terms ‘IgG4’, ‘hyperIgG4 syndrome’ and ‘IgG4 related chronic sclerosing sialadenitis’.</jats:p></jats:sec><jats:sec id="S0022215115000195_sec3"><jats:title>Results:</jats:title><jats:p>Knowledge concerning immunoglobulin G4 related chronic sclerosing sialadenitis is rapidly increasing. This new entity is part of a fibro-inflammatory corticosteroid-responsive systemic disease (immunoglobulin G4 related disease) and has been described in almost every organ. Biopsy of the submandibular gland can be diagnostic. However, the diagnosis can easily be overlooked if: clinical suspicion is not high, one is unaware of the classical morphology and/or immunoglobulin G4 staining is not performed. This paper presents a summary of the current understanding of the disease and its management.</jats:p></jats:sec><jats:sec id="S0022215115000195_sec4"><jats:title>Conclusion:</jats:title><jats:p>ENT surgeons should be aware of this new disease entity. Patients with systemic disease should be managed under a multidisciplinary team, with input from clinicians who have an interest in such diseases (such as gastroenterologists and rheumatologists), and input from histopathologists and radiologists.</jats:p></jats:sec>

Original publication

DOI

10.1017/s0022215115000195

Type

Journal article

Journal

The Journal of Laryngology & Otology

Publisher

Cambridge University Press (CUP)

Publication Date

03/2015

Volume

129

Pages

226 - 231