Measurement of Markers of Inflammation in Induced Sputum and Exhaled Air
Pavord ID., Shaw DE.
Induced sputum is safe in both children (Venge et al. 1977) and adults (Gibson et al. 2002; Green et al. 2002a), repeatable, inexpensive, and provides a clinically relevant marker of airway inflammation in the assessment and treatment of asthma. It can also be used to measure a variety of cells, effector mediators, cellular markers, and cytokines and its use has led to new insights into the pathophysiology and management of asthma and other airways disease. FENO is a reasonably reliable marker of eosinophilic airway inflammation that can be measured simply and noninvasively. The clinical value of measuring FENO has not been explored extensively but it could be a valuable tool for diagnosis and monitoring of corticosteroid-responsive airways disease in primary care. © 2008 Blackwell Publishing.