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Using data from the UK Register of HIV Sero-converters, we compared the rate of CD4 cell decline in antiretroviral-naive individuals with and without evidence of transmitted drug resistance (TDR). Although there was a suggestion that CD4 cell decline in the first year after seroconversion was faster in those with TDR,there was no evidence of a difference in the rate of decline thereafter. The virological and host determinants of this possible phenomenon are worth further exploration.


Journal article



Publication Date





1471 - 1473


Adult, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Cohort Studies, Drug Resistance, Viral, Female, HIV Infections, HIV Seropositivity, Humans, Lymphopenia, Male