Do patients with cerebral malaria have cerebral oedema? A computed tomography study.
Looareesuwan S., Warrell DA., White NJ., Sutharasamai P., Chanthavanich P., Sundaravej K., Juel-Jensen BE., Bunnag D., Harinasuta T.
Computed tomography of the brain in 10 patients with severe cerebral malaria, 5 of whom died, showed evidence of cerebral oedema in only 2 fatal cases. Small areas of altered density were seen in 4 cases; these were not associated with focal neurological signs and were still visible in convalescent scans in 2 survivors. 4 patients, including 1 of the fatalities, had completely normal scans. Cerebral oedema may occur in severe cerebral malaria but is not a consistent feature of living patients and cannot, therefore, always be the cause of their coma.