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Computed tomography of the brain in 10 patients with severe cerebral malaria, 5 of whom died, showed evidence of cerebral oedema in only 2 fatal cases. Small areas of altered density were seen in 4 cases; these were not associated with focal neurological signs and were still visible in convalescent scans in 2 survivors. 4 patients, including 1 of the fatalities, had completely normal scans. Cerebral oedema may occur in severe cerebral malaria but is not a consistent feature of living patients and cannot, therefore, always be the cause of their coma.


Journal article



Publication Date





434 - 437


Acute Disease, Adolescent, Adult, Brain, Brain Diseases, Brain Edema, Coma, Female, Humans, Malaria, Male, Middle Aged, Tomography, X-Ray Computed