Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

It is clear that latent CMV can reactivate in immunocompetent individuals, but the mechanism triggering such reactivations remains unclear. Recent clinical data suggest that reactivation can be subverted by CMV-specific T-memory. We therefore monitored CMV-specific T cells in immunocompetent mice with latent mCMV after a known reactivation trigger (LPS). LPS induced transient systemic contraction of mCMV-specific CD8 memory that was followed by transcriptional reactivation. Subsequent recovery of mCMV-specific T cells coincided with resumption of latency. These data suggest that bacterial antigen encounters can induce transient T-memory contraction, allowing viral recrudescence in hosts latently infected with herpes family viruses.

Original publication




Journal article


J Leukoc Biol

Publication Date





933 - 937


Animals, Antigens, Bacterial, CD8-Positive T-Lymphocytes, Cytomegalovirus, Cytomegalovirus Infections, Female, Flow Cytometry, Immunologic Memory, Lipopolysaccharides, Mice, Mice, Inbred BALB C, Reverse Transcriptase Polymerase Chain Reaction, Virus Activation, Virus Latency