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Cerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. They were significantly higher in patients who died (9.0 +/- 5.3 mmol/l, mean +/- SD) than in survivors (3.4 +/- 1.1 mmol/l, p = 0.0002) and had returned to normal values in each of 9 patients studied after recovery of consciousness. There was a significant negative correlation between CSF lactate and CSF glucose. All 11 patients with CSF lactate concentrations above 6 mmol/l died. CSF lactate is thus an important prognostic indicator in cerebral malaria and these findings suggest that hypoxia contributes to the pathogenesis of this disorder.

Type

Journal article

Journal

Lancet

Publication Date

06/04/1985

Volume

1

Pages

776 - 778

Keywords

Adolescent, Adult, Brain, Brain Diseases, Child, Female, Glucose, Humans, Lactates, Malaria, Male, Middle Aged, Plasmodium falciparum, Prognosis