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48 patients over 6 years of age with strictly defined cerebral malaria were randomised to receive either a single intramuscular injection of phenobarbitone (3.5 mg/kg) or placebo in a double-blind, placebo-controlled study. Phenobarbitone significantly reduced the incidence of subsequent convulsions from 54% to 12.5%, without adverse effects. A single intramuscular injection of phenobarbitone is a simple, cheap, and effective method for prevention of convulsions in cerebral malaria.


Journal article



Publication Date





64 - 66


Adolescent, Adult, Aged, Brain Diseases, Child, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Injections, Intramuscular, Malaria, Male, Middle Aged, Phenobarbital, Random Allocation, Seizures