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Antibodies were measured in the sera of fifteen patients with untreated coeliac disease and twenty-eight patients with inflammatory bowel disease. Increased levels of specific IgG, IgG1, IgG2, and IgG4 antibody to wheat gluten fraction B, measured by an enzyme-linked immunosorbent assay, were shown in the coeliac disease group, but not in the inflammatory bowel disease group. No specific IgE antibody to fraction B was detected but 33% of the patients with coeliac disease had specific short-term sensitizing (anaphylactic) IgG antibody activity (IgG S-TS) to fraction B. There was no correlation between the IgG2 or IgG4 specific antibody and the presence of IgG S-TS activity.

Type

Journal article

Journal

Clin Allergy

Publication Date

03/1985

Volume

15

Pages

155 - 162

Keywords

Adult, Antibody Specificity, Celiac Disease, Food Hypersensitivity, Glutens, Humans, Immunoglobulin E, Immunoglobulin G