Cytokine Production by Human Colonic Intraepithelial Lymphocytes in Controls and Ulcerative Colitis
Hoang P., Dalton HR., de Silv HJ., Jewell DP.
Using an ELISA technique, concentrations of γ‐interferon and interleukin‐2 were assayed in the supernatants of colonic intraepithelial lymphocytes cultured with or without phytohaemagglutinin (PHA). IntraepitheHal lymphocytes produced low concentrations of γ‐interferon and interleukin‐2 when stimulated with PHA, but significantly more than when unstimulated (p < 0.05). There was no difference in production of these cytokines by IEL from control or inflammatory bowel disease.