Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Carnitine is necessary for the transport of fatty acids across the inner mitochondrial membrane, and depletion in response to Intralipid infusion has previously been demonstrated. This study investigates whether orally administered L-carnitine increases tolerance to a lipid load given intravenously. Eight patients with active inflammatory bowel disease, being treated with intravenous prednisolone, were studied. Intralipid was infused on two occasions. Triglycerides and ketone bodies rose in a reproducible manner. Carnitine did not influence these changes. Carnitine excretion rose after an oral dose indicating that carnitine was absorbed, but carnitine excretion was increased in the steroid-treated individuals and rose after oral prednisolone in two healthy subjects. It is concluded that under the conditions of this study oral carnitine is without demonstrable effect on the handling of an intravenous lipid load.

Type

Journal article

Journal

Clin Nutr

Publication Date

10/1984

Volume

3

Pages

141 - 145