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Human colonic intraepithelial lymphocytes from control subjects down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens or phytohaemagglutinin (PHA). In contrast, human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens. These findings may be important in the development and maintenance of the mucosal immunological activation of inflammatory bowel disease.

Type

Journal article

Journal

Clin Exp Immunol

Publication Date

07/1993

Volume

93

Pages

97 - 102

Keywords

Aged, Aged, 80 and over, Antigens, Bacterial, Cells, Cultured, Colitis, Ulcerative, Colon, Crohn Disease, Down-Regulation, Epithelium, Female, Humans, Inflammatory Bowel Diseases, Intestinal Mucosa, Lymphocyte Activation, Male, Middle Aged, Phytohemagglutinins, T-Lymphocytes, T-Lymphocytes, Regulatory, Tetanus Toxoid