Genomic Sequencing from Sputum for Tuberculosis Disease Diagnosis, Lineage Determination, and Drug Susceptibility Prediction
Nilgiriwala K., Rabodoarivelo M-S., Hall MB., Patel G., Mandal A., Mishra S., Andrianomanana FR., Dingle K., Rodger G., George S., Crook DW., Hoosdally S., Mistry N., Rakotosamimanana N., Iqbal Z., Grandjean Lapierre S., Walker TM.
Universal access to drug susceptibility testing for newly diagnosed tuberculosis patients is recommended. Access to culture-based diagnostics remains limited, and targeted molecular assays are vulnerable to emerging resistance mutations.