Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A long-term observational study of Hb E-beta-thalassemia in Sri Lanka is beginning to define some of the genetic and environmental factors that are responsible for its remarkable phenotypic variability. In this population there is a very small difference between the steady-state hemoglobin levels between the mild and severe phenotypes, and it has been possible to stop transfusion in many of those who have been on long-term treatment of this kind. These preliminary observations, made over the last 7 years, provide directions for future research into this increasingly important disease.

Original publication




Conference paper

Publication Date





33 - 39


Adolescent, Adult, Blood Transfusion, Case Management, Child, Child, Preschool, Combined Modality Therapy, Erythropoietin, Female, Genetic Heterogeneity, Hemoglobin E, Hemoglobins, Humans, Infant, International Cooperation, Iron Overload, Longitudinal Studies, Male, Middle Aged, Phenotype, Pregnancy, Pregnancy Complications, Hematologic, Severity of Illness Index, Splenectomy, Sri Lanka, Transfusion Reaction, beta-Thalassemia