Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

BackgroundThe effects of high flow nasal cannula (HFNC) on adult patients after extubation remain controversial. We aimed to further determine the effectiveness of HFNC in comparison to noninvasive positive pressure ventilation (NIPPV) and conventional oxygen therapy (COT).MethodsThe Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trails (CENTRAL) as well as the Information Sciences Institute (ISI) Web of Science were searched for all the controlled study comparing HFNC with NIPPV and COT in adult patients after extubation. The primary outcome was rate of reintubation and the secondary outcomes were intensive care unit (ICU) mortality and length of ICU stay (ICU LOS).ResultsEight trials with a total of 2936 patients were pooled in our final studies. No significant heterogeneity was found in outcome measures. Compared with COT, HFNC was associated with lower rate of reintubation (Z = 2.97, P = 0.003), and the same result was found in the comparison between HFNC and NIPPV (Z = 0.87, P = 0.38). As for the ICU mortality and ICU LOS, we did not find any advantage of HFNC over COT or NIPPV.ConclusionsIn patients after extubation, HFNC is a reliable alternative of NIPPV to reduce rate of reintubation compared with COT.

Original publication




Journal article


BMC pulmonary medicine

Publication Date





Department of Respiratory and Critical Care, Sichuan University, No.37 Guoxue Alley, Chengdu, 610041, China.


Humans, Oxygen, Length of Stay, Oxygen Inhalation Therapy, Positive-Pressure Respiration, Hospital Mortality, Intubation, Intratracheal, Adult, Intensive Care Units, Randomized Controlled Trials as Topic, Airway Extubation, Noninvasive Ventilation, Cannula