Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne bla KPC Carbapenemase in Enterobacterales in the United Kingdom from 2009 to 2014
Stoesser N., Phan HTT., Seale AC., Aiken Z., Thomas S., Smith M., Wyllie D., George R., Sebra R., Mathers AJ., Vaughan A., Peto TEA., Ellington MJ., Hopkins KL., Crook DW., Orlek A., Welfare W., Cawthorne J., Lenney C., Dodgson A., Woodford N., Walker AS., Aiken Z., Akinremi O., Ali A., Cawthorne J., Cleary P., Crook DW., Decraene V., Dodgson A., Doumith M., Ellington MJ., George R., Grimshaw J., Guiver M., Hill R., Hopkins KL., Jones R., Lenney C., Mathers AJ., McEwan A., Moore G., Neilson M., Neilson S., Peto TEA., Phan HTT., Regan M., Seale AC., Stoesser N., Turner-Gardner J., Watts V., Walker AS., Walker J., Wyllie D., Welfare W., Woodford N.
Carbapenem resistance in Enterobacterales is a public health threat. Klebsiella pneumoniae carbapenemase (encoded by alleles of the bla KPC family) is one of the most common transmissible carbapenem resistance mechanisms worldwide. The dissemination of bla KPC historically has been associated with distinct K. pneumoniae lineages (clonal group 258 [CG258]), a particular plasmid family (pKpQIL), and a composite transposon (Tn 4401 ).