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In our projects we aim to characterize the systemic, intestinal and liver immune response in patients with PSC and IBD through a combination of high throughput techniques, including multicolour flow cytometry, CyTOF mass cytometry, molecular biology and in situ analysis. Furthermore, we are using state-of-the-art whole genome shotgun sequencing to investigate both microbiome and patients intestinal transcriptomes and identify novel pathways through which microbial products can influence the host immune function.

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This is what we are focusing on right now:

  • Characterization of the mucosal and systemic immune response in patients with IBD and PSC
  • Analysis of the microbiome-host interaction in PSC-IBD using whole genome shotgun sequencing
  • Investigating the gut-vascular barrier in patients with IBD and PSC