Research

Fundamental and Translational Research

Research within the Translational Gastroenterology Unit involves fundamental research on cellular and molecular pathways of innate and adaptive immunity in the intestine, inflammation, and immune system-bacteria interactions. Scientific findings are applied to the study of gastrointestinal diseases including inflammatory bowel disease, chronic liver disease, and cancer. In conjunction with the careful study of clinically and genetically defined patient cohorts, these efforts help identify novel therapeutic strategies and methods for optimising current treatment protocols.

Principal Investigators (alphabetical order)

	Dr. Carolina Arancibia Translational Medicine, Lead Mucosal Immunology		Prof. Simon Leedham Adult gastrointestinal stem cells and role in colorectal cancer
	Prof. Ellie Barnes Experimental Medicine in liver disease, immunology, vaccines and hepatitis.		Dr. Kevin Maloy Host-pathogen interactions in the intestine
	Dr. Elizabeth Bird-Lieberman Upper Gastrointestinal Tract		Dr. Philippa Matthews Immunology, HBV infection
	Dr. Oliver Brain Gastroenterology		Prof. Fiona Powrie Immunology of IBD and colorectal cancer
	Dr. Jeremy Cobbold Gastroenterology, Hepatology		Prof. Jack Satsangi Genetics, Genomics, Immunology & Infectious Disease
	Dr. James East *Cellular immunology, In vivo* imaging, SNP typing**		Prof. Alison Simmons Molecular mechanisms of innate immunity and pathogen sensing
	Dr. Alessandra Geremia Academic Clinical Lecturer		Prof. Simon Travis, FRCP *Drug discovery and In Vivo* Imaging**
	Prof. Satish Keshav Translational research in gastrointestinal immunology		Prof. Holm Uhlig Paediatric gastroenterology and mucosal immunology
	Prof. Paul Klenerman Antiviral immunity and hepatology		Dr Alissa Walsh Digital health, Remote monitoring of chronic disease