Sujata Biswas
As a Gastroenterology trainee I became interested in colorectal cancer genetics after coming across several patients with polyposis syndromes and familial predisposition to cancer without a well-defined genetic basis. I decided to pursue research into the role of the microenvironment in gastrointestinal stem cell biology and am currently an MRC clinical research training fellow. My PhD project examines the role of intestinal mesenchyme in creating morphogen gradients in homeostasis and inflammation. I work on human tissue as well as in vivo and in vitro models of microenvironmental disruption.
Recent publications
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
Journal article
Murphy L. et al, (2025), Science, 389
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling
Journal article
Mulholland EJ. et al, (2025), Nature Communications, 16
Evolutionary history of human colitis-associated colorectal cancer
Journal article
Baker A-M. et al, (2019), Gut, 68, 985 - 995
Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis
Journal article
Lee LYW. et al, (2019), Clinical Cancer Research, 25, 629 - 640
The evolutionary landscape of colorectal tumorigenesis
Journal article
Cross W. et al, (2018), Nature Ecology & Evolution, 2, 1661 - 1672
