Sheila Lumley
DPhil student
I am an infectious diseases registrar currently undertaking a Dphil in the Matthews group supported by a Wellcome Trust Clinical Research Training Fellowship.
I have been working with the Matthews group alongside my clinical training since 2015, developing my interest in viral genomics and the application of novel sequencing platforms to clinical practice. I am currently investigating a range of diagnostic platforms, including lateral flow devices, LAMP, and sequencing, for diagnosis of respiratory viruses including SARS-CoV-2.
I am working closely with colleagues at Oxford University Hospitals NHS Foundation Trust to deliver a large scale staff SARS-CoV-2 testing programme (over 12,500 staff tested to date), to provide enhanced infection prevention control and answer critical questions about post-infection immunity.
I continue to contribute to clinical work, and co-ordinate and deliver medical student teaching as a Teaching Fellow at Green Templeton College and as a lecturer for medical school infection teaching programs.
Recent publications
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A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults
Journal article
Maponga TG. et al, (2025), Annals of Hepatology, 30, 101763 - 101763
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Next-Generation Sequencing Methods for Sensitive Characterisation of Hepatitis B Viral Genomes: A European Multicentre Study
Preprint
Fu MX. et al, (2025)
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Eligibility for hepatitis B virus (HBV) treatment and prevalence of drug resistance in a Ugandan population cohort
Preprint
Lumley SF. et al, (2025)
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Hepatitis B virus resistance to nucleos(t)ide analogue therapy: WHO consultation on questions, challenges, and a roadmap for the field
Journal article
Lumley SF. et al, (2025), The Lancet Microbe, 101076 - 101076
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Whole genome sequencing of hepatitis B virus using tiled amplicon (HEPTILE) and probe based enrichment on Illumina and Nanopore platforms
Journal article
Lumley SF. et al, (2025), Scientific Reports, 15