Holm Uhlig
Professor of Paediatric Gastroenterology
The gastrointestinal immune system has evolved to counteract the invasion of pathogens. To allow a strong inflammatory immune response during infection but avoid tissue damage there is a need for effective immune regulation. Defects in immune regulation lead to immunopathology such as inflammatory bowel disease or celiac disease.
About one-fifth of all patients with IBD present with initial symptoms during childhood and adolescents. In particular in the very young children patients, an underlying immunodeficiency may cause IBD-like symptoms. The analysis of immune deviation in children with IBD and IBD-like symptoms may contribute to the understanding of the complex puzzle of molecular mechanisms involved in IBD.
To investigate novel genetic defects to lead to very early onset intestinal inflammation we established the COLORS in IBD study (COLitis of early Onset - Rare diseaseS withIN IBD). COLORS in IBD has several international collaborators.
We investigate functional mechanisms of intestinal inflammation: antimicrobial activity in phagocytes, regulatory T cells, and epithelial barrier defects.
One key interest of the lab is to understand cytokine responses, in particular, IL-6 and IL-10 family cytokine responses.
A further area of interest is the immune response in patients with defects in the PI3K signaling pathway. One large group of patients with defects in this pathway have mutations in the phosphatase PTEN. Due to heterozygous mutations in the PTEN gene patients develop the PTEN hamartoma tumor syndrome which includes Bannayan Riley Ruvalcaba syndrome and Cowden's syndrome. We investigate the functional consequences of PTEN deficiency for the development of the mucosa-associated lymphoid tissue, B and T cell responses.
Recent publications
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Upadacitinib for Induction of Remission in Pediatric Ulcerative Colitis: An International Multi‑center Study.
Journal article
Yerushalmy-Feler A. et al, (2024), J Crohns Colitis
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A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.
Journal article
Thomas T. et al, (2024), Nature immunology, 25, 2152 - 2165
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The circulating methylome in childhood-onset inflammatory bowel disease.
Journal article
Noble A. et al, (2024), Journal of Crohn's & colitis
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Biallelic PI4KA Mutations Disrupt B-Cell Metabolism and Cause B-Cell Lymphopenia and Hypogammaglobulinemia.
Journal article
Saettini F. et al, (2024), Journal of clinical immunology, 45
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Successful Allogeneic Hematopoietic Cell Transplantation for Patients with IL10RA Deficiency in Japan.
Journal article
Tomomasa D. et al, (2024), Journal of clinical immunology, 45