I’ve been working with Professor Barnes since 2007 and have mainly been working on the Phase 1 clinical candidate HCV vaccine studies that have been carried out in Oxford, looking at their immunogenicity in healthy volunteers and HCV patients.
I have also been involved in the NGS work of various pathogenic viruses, particularly HCV, that has been set up in collaboration with the Welcome Trust Centre for Human Genomics.
In addition to these main roles I have been looking at the immune response to HEV in HEV exposed individuals from Cornwall and Oxford in a collaboration with Dr Harry Dalton.
HCV sequencing and vaccination, all aspects of HEV infection and viral sequencing
PEACHI vaccine study, STOP-HCV viral sequencing and host immune response to HEV infection
Illumina and Nanopore methods for whole genome sequencing of hepatitis B virus (HBV)
McNaughton AL. et al, (2019), Scientific Reports, 9
Resistance analysis of genotype 3 hepatitis C virus indicates subtypes inherently resistant to nonstructural protein 5A inhibitors
Smith D. et al, (2019), Hepatology, 69, 1861 - 1872
Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse
Bonsall D. et al, (2018), Infection and Drug Resistance, Volume 11, 1119 - 1135
Rolling circle amplification and nanopore-based deep sequencing of full-length HBV genomes
Mcnaughton A. et al, (2018), Journal of Hepatology, 68, S762 - S762
A Novel Vaccine Strategy Employing Serologically Different Chimpanzee Adenoviral Vectors for the Prevention of HIV-1 and HCV Coinfection.
Hartnell F. et al, (2018), Frontiers in immunology, 9