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Publications

Redefining clinical practice through spatial profiling: a revolution in tissue analysis.

Mulholland EJ. and Leedham SJ., (2024), Annals of the Royal College of Surgeons of England, 106, 305 - 312

Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.

Malla SB. et al, (2024), Nat Genet

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.

Beach C. et al, (2023), The Journal of clinical investigation, 133

Poor diagnostic reproducibility in the identification of non-conventional dysplasia in colitis impacts the application of histological stratification tools.

Nasreddin N. et al, (2023), Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Virtual alignment of pathology image series for multi-gigapixel whole slide images.

Gatenbee CD. et al, (2023), Nature communications, 14

β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer.

Suzuki T. et al, (2023), Cancer immunology research

Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

Flanagan DJ. et al, (2023), Nature Communications, 14

Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features

Flanagan DJ. et al, (2022), Nature Communications, 13

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia.

Gil Vazquez E. et al, (2022), Cell stem cell, 29

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells.

Cañellas-Socias A. et al, (2022), Nature, 611, 603 - 613

Homeostasis limits keratinocyte evolution.

Schenck RO. et al, (2022), Proc Natl Acad Sci U S A, 119

The Emerging Era of Personalised Medicine in Advanced Colorectal Cancer.

Wu CW. et al, (2022), Journal of gastroenterology and hepatology

Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data.

Fisher NC. et al, (2022), Clinical cancer research : an official journal of the American Association for Cancer Research

Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer.

Hashimoto T. et al, (2022), British journal of cancer

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

Vazquez EG. et al, (2022)

Germline variant testing in serrated polyposis syndrome

Murphy A. et al, (2022), Journal of Gastroenterology and Hepatology, 37, 861 - 869

Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.

Corry SM. et al, (2022), Gut

Immunosuppressive niche engineering at the onset of human colorectal cancer.

Gatenbee CD. et al, (2022), Nat Commun, 13

Gattaca: Base pair resolution mutation tracking for somatic evolution studies using agent-based models.

Schenck RO. et al, (2022), Molecular biology and evolution

The molecular subtyping resource (MouSR): a user-friendly tool for rapid biological discovery from transcriptional data.

Ahmaderaghi B. et al, (2022), Disease models & mechanisms

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